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KMID : 0882420070730001022
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Korean Journal of Medicine
2007 Volume.73 No. 0 p.1022 ~ p.1028
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Small cell carcinoma of the gall bladder: Two case reports
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Lee Myoung-Hee
Park Tae-Jin
Lee Hyun-Woo
Kang Seok-Yun
Choi Jin-Hyuk
Kim Hugh-Chul
Yim Hyun-Ee
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Abstract
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Small cell carcinoma of the gallbladder is very rare, and represents about 5% or less of the total gallbladder cancer. This rare pathological type of gall bladder cancer has a very poor prognosis requiring intensive adjuvant treatment. It presents with highly malignant and devastating features, even with the adjuvant treatment. We describe the two cases of small cell carcinoma in the gallbladder. A 68-year old woman suspicious of advanced gallbladder cancer was admitted to our department for surgery. An radical cholecystectomy with retropancreatic lymph node dissection was performed. After a pathological diagnosis, we started adjuvant chemotherapy (1,000 mg/m2 5-fluorouracil for 3 days; 100 mg/m2 etoposide for 3 days ; 25 mg/m2 cisplatin for 3 days; every 3 weeks). After 2-cycles of chemotherapy, the patient refused all kinds of treatment because of nausea and vomiting. We followed the patient every 6 months and there was no evidence of recurrence of the tumor by an abdominal US 4 years after surgery. Another 36-year old woman suspicious of gallbladder cancer and cholecystitis, underwent a laparascopic cholecystectomy. After a pathological diagnosis, the patient received 6-cycles of systemic chemotherapy (100 mg/m2 etoposide for 3days; 25 mg/m2 cisplatin, for 3 days; every 3 weeks) and external irradiation to the gallbladder bed with a total dose of 4,000 cGy. There was no evidence of recurrence of tumor by abdominal CT three months after surgery. We discuss the characteristics and treatment of this rare tumor.(Korean J Med 73:S1022-S1028, 2007)
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KEYWORD
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Small cell carcinoma, Gall bladder
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